Nchịkọta granulomatosis nke Wegener bụ ọrịa autoimmune nke na-ezo aka na ọrịa ndị siri ike ma na-arịwanye elu. Usoro vascularitis na granulomatosis Wegener bụ njikọ pathologies ndị metụtara ya, n'ihi na a na-emepụta ọgwụ nje (antineutrophil cytoplasmic) na granulomatosis, nke bụ ọdịdị nke vascularitis metụtara ANCA.
Ihe kpatara granulomatosis Wegener
Nchịkọta granulomatosis nke Wegener na-ezo aka na autoimmune, n'ihi ya enwere ike inwe mkpụrụ ndụ ihe nketa. N'ezie, granulomatosis bụ nzaghachi na-ezighi ezi. Ya mere, ihe nrịbama nke ọrịa ahụ bụ ndị nrịta - HLA 添 B 批 _7, B_8, 添 DR 加 _2, nkebi DQ 抗 _w7.
Ọrụ nke pathogens na-egwuri egwu site na antineutrophil nje nje na-emeghachi na proteinase-3.
Nkịtị granulomatosis nke Wegener - mgbaàmà
Mgbaàmà nke granulomatosis na-emekarị mgbe ọ dị afọ iri anọ, ebe ọ bụ na okike enweghị ihe kpatara ya.
Granulomatosis - okpukpu nke mgbidi nke obere na ọkara arịa: vanules, capillaries, akwara na arterioles. Na usoro mmeri, akụkụ akwara iku ume, akụrụ, anya, ngụgụ na akụkụ ndị ọzọ gụnyere.
Ihe mgbaàmà ndị a bụ:
- izugbe - ụkọ ọnwụ, adịghị ike, ụbụrụ, arthralgia, ahụ ọkụ, na obere okwu, ọrịa arthritis;
- usoro ụjọ - ụdị polyneuropathy;
- anya - ischemia nke akwara anya, ikpu ìsì, episcleritis na orbital granuloma na exophthalmos;
- akpụkpọ anụ - rashes na ihe ndị na-adịghị ọcha;
- akụrụ - glomerulonephritis , nke nwere ike iji ọsọ ọsọ;
- akpa ume - ọnya na - etolite na pasent 75 nke ndị ọrịa n'ụdị infiltrates, nke na - etolite cavities n'oge mmebi; nke a nwere ike ịhụ pleurisy, ụkwara.
- traktị respiratory - na-emetụta 90% nke ndị ọrịa n'ụdị rhinitis na nzuzo purulent-haemorrhagic na ọnyá; nhichapụ nke septum nasal na-eduga ná ngọngọ akwa; Ọzọkwa, ọnya ahụ na-emetụta larynx, ntị, trachea, paranasal sinuses, nke a na-ahụ usoro nchịkwa.
Ahịa granulomatosis nke Wegener nwekwara ụdị abụọ:
- ebe obibi - ọ na-emetụta tumadi akụkụ akụkụ iku ume nke elu;
- ejiri akụkụ ya dị iche iche na - emetụta ya, nke a na - ejikọta ya na ahụ ọkụ, nkwonkwo nkwonkwo, ụkwara na obi ike.
Nchoputa nke granulomatosis Wegener
Nchoputa a bu nke onye nyocha onu ogugu bu nke dabeere na otutu data:
- nyocha ọbara - biochemical na n'ozuzu, nke na-enweghị ike gosi granulomatosis, ma aka na-achịkwa ọrịa ndị ọzọ;
- mmamịrị analysis - ọ nwere ike ikwenye ma ọ bụ wepu akụrụ emebi (ụdị nke ọrịa kpebisiri ike);
- X-ray nke sinist na tarraj (paranasal sinus) (ihe omimi nke a na-enye nkọwa zuru ezu karia ihe nke X-ray nwetara);
- biopsy - nani ụzọ nke kwadoro ma ọ bụ ịgọnahụ ọnụnọ nke granulomatosis; ndị dọkịta na-ewepụ anụ ahụ site na imi ma ọ bụ akpịrị, na n'ọnọdụ ụfọdụ, akụrụ na akpa ume.
Nlekọta nke granulomatosis Wegener
A na-agwọ ọrịa ahụ, tumadi, site n'inweta corticosteroids na cytostatics, nke belata ọrụ
Site na mmebi akụrụ siri ike, n'ọnọdụ ụfọdụ, onye ọrịa chọrọ mkpagharị akụrụngwa.
Nlekọta granulomatosis nke Wegener - prognosis
Ọ bụrụ na a malitebeghị ọgwụgwọ n'oge kwesịrị ekwesị, mgbe ahụ, prognosis na-adịghị mma ga-emezu n'ime ọnwa 6 ruo ọnwa 12, ọnụ ọgụgụ ndụ n'ogologo adịghịkwa karịa ọnwa 5.
N'ihe banyere ọgwụgwọ, mgbapụta dị ihe dị ka afọ 4, na ụfọdụ n'ime afọ iri. Ngwọta zuru oke n'oge a nke mmepe nke ọgwụgwọ agaghị ekwe omume.