Ndokwa preparations Bisphosphonate

A pụrụ iche ụdị ọgwụ ndị na-egbochi ọkpụkpụ ọdịda na mbibi site na osteoclasts na-arụsi ọrụ ike na ọgwụgwọ osteoporosis na ụmụ nwanyị. Ngwakọta Bisphosphonate ma ọ bụ dysphosphonate bụ ogidi ndị sịntetik na-emekarị ka ha dị ka pyrophosphates bụ ndị na-eguzogide resorption. Taa, a na-ewere ha nanị ọgwụ maka osteoporosis ma gosipụta irè.

Aha nke nhazi nke bisphosphonate

Ụdị ọgwụ a na-atụle bụ nkewa n'ime 2 nnukwu ìgwè - ọgwụ ndị nwere nitrogen na ọgwụ ọjọọ na-enweghị ya.

Ụdị nke mbụ gụnyere:

1. Alendronic acid. Mkpali na-akpali mweghachi nke ihe owuwu ahụ na nhazi usoro akụkọ ihe mere eme ziri ezi nke ọkpụkpụ, na-achịkwa usoro mgbanwe na resorption. A na-emekarị ka ọkpụkpụ osteoporosis, ọrịa hypercalcemia ọjọọ na deforming osteitis, na-egbochi mgbawa;
2. Zolendronate ma ọ bụ zoledronic acid. Na-ekpuchi ọrụ nke osteoclasts, ma ọ dịghị emetụta usoro nke ịmịkọ ọkpụkpụ, ihe ndị na-emepụta ihe na anụ ahụ e guzobere;
3. Clodronic acid (Clodron, Bonefos). Na-ebelata ihe ize ndụ nke ịkpụkpụ ọkpụkpụ, na-emepụta mmetụta nke anesthetic. A na-eji ya na-agwọ ọgwụ, na-eji aka ya ebibi mbibi pathological macrophages;
4. Bondronate (ibadronic acid). Ezubere maka maka ịgwọ ụmụ nwanyị, nke kachasị mkpa na oge ahụ. A na-ejikwa ya n'oge ọgwụgwọ ndochi.

Bezazotistye bisphosphonates nwere ike were ya na metastases na ọkpụkpụ, ụdị ọrịa siri ike, hypercalcemia. N'okwu a, nhọrọ ziri ezi bụ usoro ziri ezi, nke dọkịta ga-agbakọ. Ma ọ bụghị ya, karịsịa site na nkwụsịtụ, nsogbu nwere ike ime.

Ndepụta nke bisphosphonate preparations na-enweghị nitrogen:

1. Tiludronate. Na-eme ka njupụta nke ọkpụkpụ anụ, na-emekarị ka ọ bụrụ na e nwere nrụrụ na mgbawa;
2. Xidiphon, Pleistat ma ọ bụ sodium etidronate. A na-ejikarị ya eme ihe na mgbagwoju anya nke ọrịa Paget, ọrịa ndị na-agwọ ọrịa, hypercalcemia, oké osteoporosis;
3. Ibandronate sodium. Ọ na-enye aka nke ọma na ọgwụ ọgwụ ọjọọ na-eme ka a gbanwee ọgwụgwọ na oge post-menopausal;
4. Na-ehicha. Na-egbochi mbibi nke kristal calcium, mmepe nke osteolysis. A na-eme ọgwụ maka ọgwụ ọjọọ, ọrịa leukemias, lymphomas, nnukwu metastases.

Ntuziaka maka bisphosphonates

A nabatara ọgwụ ndị a kọwara n'elu dịka nkwenye nke dọkịta dị 1 oge kwa ụbọchị.

Bisphosphonates na-edozi nke ọma, n'ihi ya, ọ dị mkpa na a ga-asacha ha na mmiri dị ọcha na mmiri dị ọkụ maka ihe kacha mma.

Ọ bụ ihe na-achọsi ike ịme nkwụsị n'etiti nnata nri na bisphosphonate. A ga - ewebe mbadamba ihe dị ka awa ise tupu nri na afo efu - ọ gafeghi minit 60 mgbe nri rie.

Otu n'ime ihe ndị na-adịghị mma nke ìgwè ọgwụ a bụ ikike ha nwere ịkpasu mucosa nke esophagus iwe, iji kpasuo ọnyá ekpenta n'isi ya. Ya mere, mgbe ị na-ewere bisphosphonates, ị gaghị enwe ike ịrahụ ụra ozugbo, ọ dị mkpa ka 90 nkeji (opekempe) dị n'ọnọdụ ziri ezi, ịnwere ike ịnọdụ ala, ma ọ ka mma ịga ụkwụ ma ọ bụ rụọ ọrụ ụlọ. Nke a ga - egbochi mmetụta ndị dị otú ahụ dị ka nrịkasi obi , gbanwee reflux na esophagitis.